Ammonia → HCID 69078717, compound

HRID 1517393Notes

Reaction equation

C[O:2][C:3]1C=C(C2C=CC3N=CN=CC=3N=2)C=C[C:8]=1OC.[NH2:21][C:22]1[N:23]=[C:24]([N:42]2[CH2:47][CH2:46][NH:45][CH2:44][CH:43]2[C:48](=[O:57])[NH:49][C:50]2[CH:55]=[CH:54][CH:53]=[C:52]([CH3:56])[CH:51]=2)[C:25]2[N:31]=[C:30]([C:32]3[CH:37]=[CH:36][C:35]([O:38][CH3:39])=[C:34]([O:40][CH3:41])[CH:33]=3)[CH:29]=[CH:28][C:26]=2[N:27]=1.N.CNC>>[C:3]([NH:21][C:22]1[N:23]=[C:24]([N:42]2[CH2:47][CH2:46][NH:45][CH2:44][CH:43]2[C:48](=[O:57])[NH:49][C:50]2[CH:55]=[CH:54][CH:53]=[C:52]([CH3:56])[CH:51]=2)[C:25]2[N:31]=[C:30]([C:32]3[CH:37]=[CH:36][C:35]([O:38][CH3:39])=[C:34]([O:40][CH3:41])[CH:33]=3)[CH:29]=[CH:28][C:26]=2[N:27]=1)(=[O:2])[CH3:8]

Participants

Reactant 4

HCID 222Ammonia

HCID 674Dimethylamine

HCID 68916896HCID 68916896, compound

HCID 69077498HCID 69077498, compound

Product 1

HCID 69078717HCID 69078717, compound

Procedure

2-acetamido-4-[(N-3-methyl-phenylcarbamoyl)-piperazin-1-yl]-6-(3,4-dimethoxyphenyl)-pyrido[3,2-d]pyrimidine was synthesized from 2-chloro-4-(4-[3-methylphenyl)amino]carbonyl]piperazin-1-yl)-6-(3,4-dimethoxyphenyl)pyrido[3,2-d]pyrimidine. In a first step, 2-amino-4-[(N-3-methyl-phenylcarbamoyl)-piperazin-1-yl]-6-(3,4-dimethoxyphenyl)-pyrido[3,2-d]pyrimidine was synthesized according to the procedure mentioned for examples 15, using ammonia (instead of dimethylamine). Subsequent acetylation yielded the title compound.

Sources & evidence

ORD record: ord-8c7d1d319be140058ce20e49cc40b9cb
Source dataset: uspto-grants-2012_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08232278B2

Reaction notes

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