Benzene, 1-chloro-3-isocyanato- → HCID 86617307, compound

HRID 1517406Notes

Reaction equation

HRID 1517406 reaction equation
[N:1]1([C:7]2[C:8]3[N:16]=[C:15]([Cl:17])[CH:14]=[CH:13][C:9]=3[N:10]=[CH:11][N:12]=2)[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[Cl:18][C:19]1[CH:20]=[C:21]([N:25]=[C:26]=[O:27])[CH:22]=[CH:23][CH:24]=1>>[Cl:18][C:19]1[CH:20]=[C:21]([NH:25][C:26]([CH:2]2[CH2:3][NH:4][CH2:5][CH2:6][N:1]2[C:7]2[C:8]3[N:16]=[C:15]([Cl:17])[CH:14]=[CH:13][C:9]=3[N:10]=[CH:11][N:12]=2)=[O:27])[CH:22]=[CH:23][CH:24]=1

Participants

3

Reactant 2

HCID 17968Benzene, 1-chloro-3-isocyanato-HCID 714076996-Chloro-4-(piperazin-1-yl)pyrido[3,2-d]pyrimidine

Product 1

HCID 86617307HCID 86617307, compoundYield 99.2%

Procedure

This compound was synthesized from 4-(piperazin-1-yl)-6-chloro-pyrido[3,2-d]pyrimidine (2.5 g, 10 mmole) and 3-chlorophenyl isocyanate (1.54 g, 10 mmole) using the procedure of example 69, resulting in the pure title compound (4.0 g, 99%) as a white solid which was characterized by its mass spectrum as follows: MS (m/z): 403.1 ([M+H]+, 100).

Sources & evidence

ORD record
ord-d5ade0e8ee8146b7ab48089f9a4cf6a1
Source dataset
uspto-grants-2012_07
Patent number
US08232278B2

Reaction notes

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