3,4-Dichlorobenzeneboronic acid → 6-(3,4-Dichlorophenyl)-4-(morpholin-4-yl)pyrido[3,2-d]pyrimidine

HRID 1517419Notes

Reaction equation

HRID 1517419 reaction equation
[O:1]1[CH2:6][CH2:5][N:4]([C:7]2[C:8]3[N:16]=[C:15](Cl)[CH:14]=[CH:13][C:9]=3[N:10]=[CH:11][N:12]=2)[CH2:3][CH2:2]1.[Cl:18][C:19]1[CH:20]=[C:21](B(O)O)[CH:22]=[CH:23][C:24]=1[Cl:25]>>[O:1]1[CH2:6][CH2:5][N:4]([C:7]2[C:8]3[N:16]=[C:15]([C:22]4[CH:21]=[CH:20][C:19]([Cl:18])=[C:24]([Cl:25])[CH:23]=4)[CH:14]=[CH:13][C:9]=3[N:10]=[CH:11][N:12]=2)[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 27343303,4-Dichlorobenzeneboronic acidHCID 714076986-Chloro-4-(morpholin-4-yl)pyrido[3,2-d]pyrimidine

Product 1

HCID 689186546-(3,4-Dichlorophenyl)-4-(morpholin-4-yl)pyrido[3,2-d]pyrimidineYield 97%

Procedure

The reaction of 4-morpholino-6-chloro-pyrido[3,2-d]pyrimidine and 3,4-dichlorophenylboronic acid afforded the pure title compound (yield 97%) as a yellowish solid which was characterized by its mass spectrum as follows: MS (m/z): 361.2 ([M+H]+, 100).

Sources & evidence

ORD record
ord-fb0891ec3b39468caedbdf8920262ca7
Source dataset
uspto-grants-2012_07
Patent number
US08232278B2

Reaction notes

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