Acetic Anhydride → N-(6-Chloro-4-oxo-1,4-dihydropyrido[3,2-d]pyrimidin-2-yl)acetamide

HRID 1517423Notes

Reaction equation

HRID 1517423 reaction equation
[NH2:1][C:2]1[NH:3][C:4](=[O:13])[C:5]2[N:11]=[C:10]([Cl:12])[CH:9]=[CH:8][C:6]=2[N:7]=1.[C:14](OC(=O)C)(=[O:16])[CH3:15]>>[C:14]([NH:1][C:2]1[NH:3][C:4](=[O:13])[C:5]2[N:11]=[C:10]([Cl:12])[CH:9]=[CH:8][C:6]=2[N:7]=1)(=[O:16])[CH3:15]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 1357416292-Amino-6-chloropyrido[3,2-d]pyrimidin-4(1H)-one

Product 1

HCID 135978119N-(6-Chloro-4-oxo-1,4-dihydropyrido[3,2-d]pyrimidin-2-yl)acetamideYield 80%

Procedure

A suspension of 2-amino-6-chloro-pyrido[3,2-d]pyrimidin-4(3H)-one (1.96 g, 10 mmol) in acetic anhydride (200 ml) was refluxed for 2 hours till a clear solution was obtained. The solvents were evaporated in vacuo till crystallization started. The precipitate was filtered off and dried under vacuum yielding the pure title compound (2 g, 80%) which was characterised as follows:

Workup

  1. temperaturewas refluxed for 2 hours till a clear solution
  2. customwas obtained
  3. customThe solvents were evaporated in vacuo till crystallization
  4. filtrationThe precipitate was filtered off
  5. customdried under vacuum

Sources & evidence

ORD record
ord-ac5af4683b854fe396167fdb3889dd7b
Source dataset
uspto-grants-2012_07
Patent number
US08232278B2

Reaction notes

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