Phosphorus sulfide (P2S5) → HCID 178488520, compound

HRID 1517426Notes

Reaction equation

HRID 1517426 reaction equation
[NH2:1][C:2]1[NH:3][C:4](=O)[C:5]2[N:11]=[C:10]([C:12]3[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[C:14]([O:20][CH3:21])[CH:13]=3)[CH:9]=[CH:8][C:6]=2[N:7]=1.P12(SP3(SP(SP(S3)(S1)=S)(=S)S2)=S)=[S:24]>N1C=CC=CC=1>[NH2:1][C:2]1[NH:3][C:4](=[S:24])[C:5]2[N:11]=[C:10]([C:12]3[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[C:14]([O:20][CH3:21])[CH:13]=3)[CH:9]=[CH:8][C:6]=2[N:7]=1

Participants

4

Reactant 2

HCID 14817Phosphorus sulfide (P2S5)HCID 1362700182-Amino-6-(3,4-dimethoxyphenyl)pyrido[3,2-d]pyrimidin-4(1H)-one

Product 1

HCID 178488520HCID 178488520, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A suspension of 2-amino-6-(3,4-dimethoxyphenyl)-pyrido[3,2-d]pyrimidin-4(3H)one (100 mg, 0.34 mmol) and phosphorus pentasulfide (163 mg, 0.37 mmol) in pyridine (10 ml) was refluxed for 4 hours. The solvents were evaporated in vacuo. The residue was re-suspended in a small amount of water and filtered off, yielding the title compound which was used without any further purification and which was characterised as follows: MS (m/z): 315 ([M+H]+, 100).

Workup

  1. temperaturewas refluxed for 4 hours
  2. customThe solvents were evaporated in vacuo
  3. filtrationfiltered off

Sources & evidence

ORD record
ord-75582b8684af4300814bfd58f0240282
Source dataset
uspto-grants-2012_07
Patent number
US08232278B2

Reaction notes

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