反应详情

A suspension of 2-amino-6-(4-fluorophenyl)-pyrido(3,2-d)pyrimidin-4(3H)one (2.56 g, 10 mmol) and phosphorus pentasulfide (2.5 g, 11 mmol) in pyridine (200 ml) was refluxed for 4 hours. The reaction mixture was cooled down and the precipitate was filtered off, yielding the pure title compound, which was used without any further purification (2 g, yield: 73%) and was characterised by its mass spectrum as follows: MS (m/z): 273 ([M+H]+, 100)

1. temperaturewas refluxed for 4 hours
2. temperatureThe reaction mixture was cooled down
3. filtrationthe precipitate was filtered off