6-(4-Fluorophenyl)-4-phenoxypyrido[3,2-d]pyrimidine → 4-Ethoxy-6-(4-fluorophenyl)pyrido[3,2-d]pyrimidine

HRID 1517442Notes

Reaction equation

HRID 1517442 reaction equation
ClC1C2N=C(C3C=CC(F)=CC=3)C=CC=2N=CN=1.[O:19]([C:26]1[C:27]2[N:35]=[C:34]([C:36]3[CH:41]=[CH:40][C:39]([F:42])=[CH:38][CH:37]=3)[CH:33]=[CH:32][C:28]=2[N:29]=[CH:30][N:31]=1)[C:20]1C=CC=C[CH:21]=1>C(O)C>[CH2:20]([O:19][C:26]1[C:27]2[N:35]=[C:34]([C:36]3[CH:41]=[CH:40][C:39]([F:42])=[CH:38][CH:37]=3)[CH:33]=[CH:32][C:28]=2[N:29]=[CH:30][N:31]=1)[CH3:21]

Participants

4

Reactant 2

HCID 576983476-(4-Fluorophenyl)-4-phenoxypyrido[3,2-d]pyrimidineHCID 579067564-Chloro-6-(4-fluorophenyl)pyrido[3,2-d]pyrimidine

Product 1

HCID 576983394-Ethoxy-6-(4-fluorophenyl)pyrido[3,2-d]pyrimidineYield 87%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

This compound was synthesized from 4-chloro-6-(4-fluorophenyl)-pyrido[3,2-d]pyrimidine and ethanol in 87% yield, using the procedure described for the synthesis of 4-phenoxy-6-(4-fluorophenyl)-pyrido[3,2-d]pyrimidine. The mass spectrum characterising data was as follows: MS (m/z): 270 ([M+H]+, 100).

Sources & evidence

ORD record
ord-146409fe420f4cffaac491b39cc161a4
Source dataset
uspto-grants-2012_07
Patent number
US08232278B2

Reaction notes

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