Ammonia → 6-(4-Fluorophenyl)-2-methylpyrido[3,2-d]pyrimidin-4-amine

HRID 1517450Notes

Reaction equation

HRID 1517450 reaction equation
[CH3:1][C:2]1[N:3]=[C:4](Cl)[C:5]2[N:11]=[C:10]([C:12]3[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=3)[CH:9]=[CH:8][C:6]=2[N:7]=1.N.[NH2:21]C1C2N=C(C3C=CC(F)=CC=3)C=CC=2N=CN=1>CO>[CH3:1][C:2]1[N:3]=[C:4]([NH2:21])[C:5]2[N:11]=[C:10]([C:12]3[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=3)[CH:9]=[CH:8][C:6]=2[N:7]=1

Participants

5

Reactant 3

HCID 222AmmoniaHCID 576983546-(4-Fluorophenyl)pyrido[3,2-d]pyrimidin-4-amineHCID 576983684-Chloro-6-(4-fluorophenyl)-2-methylpyrido[3,2-d]pyrimidine

Product 1

HCID 576983296-(4-Fluorophenyl)-2-methylpyrido[3,2-d]pyrimidin-4-amineYield 99%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

This compound was synthesized from 2-methyl-4-chloro-6-(4-fluorophenyl)pyrido[3,2-d]pyrimidine and a ammonia solution in methanol in 99% yield, using the procedure described for the synthesis of 4-amino-6-(4-fluorophenyl)-pyrido[3,2-d]pyrimidine. The mass spectrum was as follows: MS (m/z): 255 ([M+H]+, 100).

Sources & evidence

ORD record
ord-f420c9272a3540209c2d02f84c1cb2e0
Source dataset
uspto-grants-2012_07
Patent number
US08232278B2

Reaction notes

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