Ethylamine → 2-Chloro-N-ethyl-6-(4-fluorophenyl)pyrido[3,2-d]pyrimidin-4-amine

HRID 1517453노트

반응식

HRID 1517453 반응식
[Cl:1][C:2]1[N:3]=[C:4](Cl)[C:5]2[N:11]=[C:10]([C:12]3[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=3)[CH:9]=[CH:8][C:6]=2[N:7]=1.[CH2:20]([NH2:22])[CH3:21]>>[Cl:1][C:2]1[N:3]=[C:4]([NH:22][CH2:20][CH3:21])[C:5]2[N:11]=[C:10]([C:12]3[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=3)[CH:9]=[CH:8][C:6]=2[N:7]=1

참가 물질

3

반응물 2

HCID 6341EthylamineHCID 596478432,4-Dichloro-6-(4-fluorophenyl)pyrido[3,2-d]pyrimidine

생성물 1

HCID 576983212-Chloro-N-ethyl-6-(4-fluorophenyl)pyrido[3,2-d]pyrimidin-4-amine수율 99%

실험 절차

was synthesized from 2,4-dichloro-6-(4-fluorophenyl)-pyrido[3,2-d]pyrimidine and ethylamine in 99% yield, as a white solid which was characterised as follows: MS (m/z): 303 ([M+H]+, 100).

출처 및 근거

ORD 기록
ord-d4c1935ef835406080e7d5f3b8353cf1
출처 데이터셋
uspto-grants-2012_07
특허 번호
US08232278B2

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