2-Methyl-4-(2-methoxyethoxy)-6-(4-fluorophenyl)-pyrido[3,2-d]pyrimidine → 2-Ethyl-6-(4-fluorophenyl)-4-(2-methoxyethoxy)pyrido[3,2-d]pyrimidine

HRID 1517454Notes

Reaction equation

HRID 1517454 reaction equation
[CH2:1]([C:3]1[N:4]=[C:5]([OH:20])[C:6]2[N:12]=[C:11]([C:13]3[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=3)[CH:10]=[CH:9][C:7]=2[N:8]=1)[CH3:2].CC1N=[C:24]([O:39][CH2:40]COC)[C:25]2N=C(C3C=CC(F)=CC=3)C=CC=2N=1>COCCO>[CH2:1]([C:3]1[N:4]=[C:5]([O:20][CH2:25][CH2:24][O:39][CH3:40])[C:6]2[N:12]=[C:11]([C:13]3[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=3)[CH:10]=[CH:9][C:7]=2[N:8]=1)[CH3:2]

Participants

4

Reactant 2

HCID 576983182-Methyl-4-(2-methoxyethoxy)-6-(4-fluorophenyl)-pyrido[3,2-d]pyrimidineHCID 178437762HCID 178437762, compound

Product 1

HCID 576983372-Ethyl-6-(4-fluorophenyl)-4-(2-methoxyethoxy)pyrido[3,2-d]pyrimidineYield 46%

Reagents, catalysts & solvents 1

HCID 80192-MethoxyethanolSolvent

Procedure

was synthesized from 2-ethyl-6-(4-fluorophenyl)-4-hydroxyl pyrido[3,2-d]pyrimidine and 2-methoxyethanol in 46% yield, using the procedure described for the synthesis of 2-methyl-4-(2-methoxyethoxy)-6-(4-fluorophenyl)-pyrido[3,2-d]pyrimidine. The mass spectrum was as follows: MS (m/z): 328 ([M+H]+, 100).

Sources & evidence

ORD record
ord-3e40a8cf533448ddacd8cacd3a1f769f
Source dataset
uspto-grants-2012_07
Patent number
US08232278B2

Reaction notes

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