Morpholine → 6-Chloro-4-(morpholin-4-yl)pyrido[3,2-d]pyrimidin-2-amine

HRID 1517460Notes

Reaction equation

HRID 1517460 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]=[C:7]([NH2:17])[N:8]=[C:9]([N:12]3[CH:16]=NC=N3)[C:10]=2[N:11]=1.N1C[CH2:22][O:21][CH2:20][CH2:19]1>C(Cl)Cl>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]=[C:7]([NH2:17])[N:8]=[C:9]([N:12]3[CH2:16][CH2:22][O:21][CH2:20][CH2:19]3)[C:10]=2[N:11]=1

Participants

4

Reactant 2

HCID 8083MorpholineHCID 576983146-Chloro-4-(1H-1,2,4-triazol-1-yl)pyrido[3,2-d]pyrimidin-2-amine

Product 1

HCID 576983306-Chloro-4-(morpholin-4-yl)pyrido[3,2-d]pyrimidin-2-amineYield 244.6%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A suspension of 6-chloro-4-[1,2,4]triazol-1-yl-pyrido[3,2-d]pyrimidin-2-ylamine (0.1 g, 0.4 mmol) and morpholine (0.07 mL, 0.8 mmol) in DCM (10 mL) was stirred at room temperature for 48 hours. After the removal of solvent, the residue was purified by flash chromatography (using 5% i-PrOH/DCM as the eluent), providing the title compound (0.26 g, 99% yield) as a yellow solid which was characterised as follows: MS (m/z) 266.0 [M+H]+.

Workup

  1. customAfter the removal of solvent
  2. customthe residue was purified by flash chromatography (

Sources & evidence

ORD record
ord-9192569dccb84dbf97a5d896373e223e
Source dataset
uspto-grants-2012_07
Patent number
US08232278B2

Reaction notes

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