p-Toluenesulfonic acid monohydrate → p-Toluenesulfonate

Participants

Reaction Steps

To compound (I) (3 g, 1.0 mol eq, limiting reagent) was charged butyronitrile (45 mL, 15 rel vol). The temperature was adjusted to 100° C. and a solution formed. p-Toluenesulfonic acid monohydrate (1.06 g, 1.0 mol eq) was dissolved in butyronitrile (18 mL, 6 rel vol). This solution was charged to the reaction. Following stirring and cooling, the solid was isolated by filtration, washed with butyronitrile (4.5 mL, 1.5 rel vol) and dried to constant weight yielding the compound (I) tosylate (3.37 g, 4.70 mmol, 85%).

Provenance & Evidence