p-Toluenesulfonic acid monohydrate → p-Toluenesulfonate

Participants

Reaction Steps

To compound (I) (5 g, 1.0 mol eq, limiting reagent) was charged methyl ethyl ketone (150 mL, 30 rel vol). The temperature was adjusted to 80° C. and a solution formed. p-Toluenesulfonic acid monohydrate (1.76 g, 1.0 mol eq) was dissolved in methyl ethyl ketone (20 mL, 5 rel vol). This solution was charged to the reaction. A line rinse of methyl ethyl ketone (5 mL, 1 rel vol) was applied. Following stirring, temperature cycling and cooling, the solid was isolated by filtration, washed twice with methyl ethyl ketone (2×25 mL, 2×5 rel vol) and dried to constant weight yielding the compound (I) tosylate (5.93 g, 8.19 mmol, 89%).

Provenance & Evidence