p-Toluenesulfonic acid monohydrate → p-Toluenesulfonate

Participants

Reaction Steps

To compound (I) (2.5 g, 1.0 mol eq, limiting reagent) was charged cyclohexanone (50 mL, 20 rel vol). The temperature was adjusted to 80° C. and a solution formed. p-Toluenesulfonic acid monohydrate (881 mg, 1.0 mol eq) was dissolved in cyclohexanone (10 mL, 4 rel vol). This solution was charged to the reaction. A cyclohexanone line rinse (2.5 mL, 1 rel vol) was charged. Following stirring, temperature cycling and cooling, the solid was isolated by filtration, washed twice with cyclohexanone (2×3.75 mL, 2×1.5 rel vol) and dried to constant weight yielding compound (I) tosylate (2.31 g, 3.14 mmol, 69%).

Provenance & Evidence