p-Toluenesulfonic acid monohydrate → p-Toluenesulfonate

Participants

Reaction Steps

To compound (I) (3 g, 1.0 mol eq, limiting reagent) was charged butan-1-ol (135 mL, 45 rel vol). The temperature was adjusted to 100° C. and a solution formed. p-Toluenesulfonic acid monohydrate (1.06 g, 1.0 mol eq) was dissolved in butan-1-ol (12 mL, 4 rel vol). This solution was charged to the reaction. A butan-1-ol line rinse (3 mL, 1 rel vol) was charged. Following stirring, temperature cycling and cooling, the solid was isolated by filtration, washed twice with butan-1-ol (2×4.5 mL, 2×1.5 rel vol) and dried to constant weight yielding compound (I) tosylate (2.96 g, 4.03 mmol, 73%).

Provenance & Evidence