Hydrochloric Acid → HCID 67391218, compound

Participants

Reaction Steps

A solution of methyl 5-[(6a-methyl-5,6,6a,7,8,9-hexahydro-4H-phenalenyl)carbamoyl]pyridine-2-carboxylate (0.161 g) in ethanol (10 ml) was added with 2 N aqueous sodium hydroxide (1 ml), and the mixture was stirred at room temperature for 3 hours. The reaction mixture was made acidic with 2 N aqueous hydrochloric acid, and the mixture was extracted with chloroform. The organic layer was washed with saturated brine, and dried over anhydrous sodium sulfate. The organic layer was concentrated under reduced pressure, and the resulting residue was recrystallized from ethanol-chloroform to obtain the title compound (0.149 g, yield: 96%) as pale yellow powdery crystals (melting point: 199-200° C.).

Provenance & Evidence