Hydrazine Sulfate → 2-(3,6-Dioxo-1,2,3,6-tetrahydropyridazin-4-yl)acetic acid

HRID 15175Notes

Reaction equation

HRID 15175 reaction equation
[O:1]=[C:2]1[C:6]([CH2:7][C:8]([OH:10])=[O:9])=[CH:5][C:4](=O)[O:3]1.S(O)(O)(=O)=O.[NH2:17][NH2:18]>O>[O:1]=[C:2]1[C:6]([CH2:7][C:8]([OH:10])=[O:9])=[CH:5][C:4](=[O:3])[NH:18][NH:17]1

Participants

4

Reactant 2

HCID 24842Hydrazine SulfateHCID 65163Aconitic anhydride

Product 1

HCID 2544282-(3,6-Dioxo-1,2,3,6-tetrahydropyridazin-4-yl)acetic acidYield 85.4%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of (2,5-dioxo-2,5-dihydro-3-furanyl)acetic acid (9 g) and hydrazine sulphate (7.2 g) in water was heated to reflux for 4 hours then allowed to cool to ambient temperature. The precipitate was filtered, washing with water then acetone. Drying in vacuo afforded a white solid (8.04 g, 82%).

Workup

  1. temperaturewas heated
  2. temperatureto reflux for 4 hours
  3. filtrationThe precipitate was filtered
  4. washwashing with water
  5. customDrying in vacuo

Sources & evidence

ORD record
ord-e3a58dcf2305483fb1ac7a8f34b6cb49
Source dataset
uspto-grants-2010_06
Patent number
US07732460B2

Reaction notes

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