反应详情

温度

0 °C

Methyl imidazol (18.1 g) in 20 ml diethyl ether is added drop wise to a stirred mixture of Octyl-2-bromoacetate (55.7 g) and diethyl ether (200 ml) and cooled to 0° C. in an ice bath. The mixture is stirred overnight to yield a two phase mixture. The top ether layer is decanted and the product is stirred in 100 ml of fresh diethyl ether for 10 minutes. The ether layer is again decanted. The product is washed in this manner 5 times to yield, after drying under vacuum, the product as a white waxy solid.

1. customto yield a two phase mixture
2. customThe top ether layer is decanted
3. stirringthe product is stirred in 100 ml of fresh diethyl ether for 10 minutes
4. customThe ether layer is again decanted
5. washThe product is washed in this manner 5 times
6. customto yield
7. customafter drying under vacuum