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Acetanilide → 2-[4-tert-Butyl-5-methoxy-2-(2-oxo-1,2-dihydro-pyridin-3-yl)-benzyl]-isoindole-1,3-dione
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetanilide | HCID 904 | — |
| 反応物 | Pyrithyldione | HCID 4994 | — |
| 反応物 | Phthalimide | HCID 6809 | — |
| 反応物 | Succinimide | HCID 11439 | — |
| 反応物 | 2-Piperidone | HCID 12665 | — |
| 反応物 | 4,4-Dimethylpiperidine-2,6-dione | HCID 14292 | — |
| 反応物 | Methanesulfonamide, N-phenyl- | HCID 70970 | — |
| 反応物 | 1,4-Butanesultam | HCID 303508 | — |
| 生成物 | 2-[4-tert-Butyl-5-methoxy-2-(2-oxo-1,2-dihydro-pyridin-3-yl)-benzyl]-isoindole-1,3-dione | HCID 46195623 | — |
反応手順
The following are prepared analogously by displacement of A-3b with the anion derived from deprotonation of the amide or sulfonamide in parentheses: I-29 (pyrrolidine-2,5-dione), I-34 (N-phenyl-methanesulfonamide), I-16 ([1,2]thiazinane 1,1-dioxide), I-23 (piperidin-2-one), I-88 (4,4-dimethyl-piperidine-2,6-dione), I-89 (PhNHAc) and I-39 (3,3-diethyl-1H-pyridine-2,4-dione).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08232271B2 |
| 出典データセット | uspto-grants-2012_07 |
| ORD ID | ord-76c1d80598934b5d85cc49c984816200 |
| 出典メモ | uspto-grants-2012_07 |