HCID 67375070, compound → HCID 46195189, compound

HRID 1517529Notes

Reaction equation

HRID 1517529 reaction equation
C([O:8][C:9]1[C:14]([C:15]2[CH:20]=[C:19]([C:21]([CH3:24])([CH3:23])[CH3:22])[C:18]([O:25][CH3:26])=[CH:17][C:16]=2[CH2:27][C:28]([NH:30][CH3:31])=[O:29])=[CH:13][CH:12]=[CH:11][N:10]=1)C1C=CC=CC=1>CO.[Pd]>[C:21]([C:19]1[C:18]([O:25][CH3:26])=[CH:17][C:16]([CH2:27][C:28]([NH:30][CH3:31])=[O:29])=[C:15]([C:14]2[C:9](=[O:8])[NH:10][CH:11]=[CH:12][CH:13]=2)[CH:20]=1)([CH3:24])([CH3:22])[CH3:23]

Participants

4

Reactant 1

HCID 67375070HCID 67375070, compound

Product 1

HCID 46195189HCID 46195189, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

step 2—A mixture of 57 (55 mg) and 10% Pd/C (10 mg) in MeOH (5 mL) at RT was stirred under 1 atmosphere of H2 for 0.5 h. The catalyst was filtered off and the filtrate was concentrated. The crude residue was purified on a preparative SiO2 TLC developed with 10% MeOH/DCM to afford 45 mg of I-10 as a white solid.

Workup

  1. filtrationThe catalyst was filtered off
  2. concentrationthe filtrate was concentrated
  3. customThe crude residue was purified on a preparative SiO2 TLC
  4. customto afford 45 mg of I-10 as a white solid

Sources & evidence

ORD record
ord-2be5e35bb1464a7ba5dfddfaf9d29696
Source dataset
uspto-grants-2012_07
Patent number
US08232271B2

Reaction notes

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