Bromine → HCID 67374784, compound

Participants

Reaction Conditions

Reaction Steps

step 1—To a solution of 3-methoxy-4-tert-butylbenzoic acid (1.0 eq, 48.02 mmol, 10.00 g and NaOAc (2.0 eq, 96.03 mmol, 7.88 g) in HOAc (75 mL) at RT was added dropwise Br2 (2.0 eq, 96.03 mmol, 4.94 mL). The resulting mixture was heated at 50° C. for 24 h, cooled to RT and poured into a mixture of ice-water. The slightly orange-colored solid was collected by suction filtration, washed with water, dried in the oven at 40° C. to afford 12.87 g of 6-bromo-4-tert-butyl-3-methoxybenzoic acid the product (118).

Provenance & Evidence