HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromonicotinaldehyde → 2-[4-[(2-Fluorospiro[4,5-dihydrothieno[2,3-c]pyran-7,4'-piperidine]-1'-yl)methyl]-3-methyl-pyrazol-1-yl]pyridine-3-carbaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromonicotinaldehyde | HCID 4714951 | — |
| Reactant | HCID 178434545 | HCID 178434545 | — |
| Product | 2-[4-[(2-Fluorospiro[4,5-dihydrothieno[2,3-c]pyran-7,4'-piperidine]-1'-yl)methyl]-3-methyl-pyrazol-1-yl]pyridine-3-carbaldehyde | HCID 58268627 | 83% |
Reaction Steps
The compound of Preparation 13 is essentially prepared as described in Preparation 12 by using 2-bromopyridine-3-carbaldehyde and 2-fluoro-1′-[(3-methyl-1H-pyrazol-4-yl)methyl]spiro[4,5-dihydrothieno[2,3-c]pyran-7,4′-piperidine]. Residue is purified by normal phase Isco chromatography to yield 83% of the title compound. MS (m/z): 427 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08232289B2 |
| Source dataset | uspto-grants-2012_07 |
| ORD ID | ord-c1ebbe08e94244fb975195e1a59fc788 |
| Source note | uspto-grants-2012_07 |