3-Cyano-2-fluoropyridine → HCID 58268556, compound

HRID 1517568Notes

Reaction equation

HRID 1517568 reaction equation
[CH3:1][C:2]1[C:6]([CH:7]=[O:8])=[CH:5][NH:4][N:3]=1.F[C:10]1[C:15]([C:16]#[N:17])=[CH:14][CH:13]=[CH:12][N:11]=1>>[CH:7]([C:6]1[C:2]([CH3:1])=[N:3][N:4]([C:10]2[C:15]([C:16]#[N:17])=[CH:14][CH:13]=[CH:12][N:11]=2)[CH:5]=1)=[O:8]

Participants

3

Reactant 2

HCID 27832543-Cyano-2-fluoropyridineHCID 1784345503-methyl-1H-pyrazole-4-carbaldehyde

Product 1

HCID 58268556HCID 58268556, compoundYield 23%

Procedure

The compound of Preparation 20 is essentially prepared as described in Preparation 19 by using 3-methyl-1H-pyrazole-4-carbaldehyde and 2-fluoropyridine-3-carbonitrile. The title compound is obtained with a yield of 23%. MS (m/z): 213 (M+1).

Workup

  1. customThe compound of Preparation 20
  2. customis essentially prepared
  3. customas described in Preparation 19

Sources & evidence

ORD record
ord-cfd5eb8e226d406c9df7fd24ce7e738f
Source dataset
uspto-grants-2012_07
Patent number
US08232289B2

Reaction notes

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