Hydrochloric Acid → HCID 71465413, compound

Participants

Reaction Steps

The solid from Example 59 was taken up in ethyl acetate/diethyl ether (1/10) (20 mL) and 2N HCl in diethyl ether (2.0 eq) was added dropwise and the mixture was stirred for 5 minutes. The reaction was concentrated in vacuo to give the title compound as a white solid. 1H NMR (DMSO-d6, 300 MHz); δ1.28 (s, 9H), 1.77-1.83 (m, 1H), 2.42-2.53 (m, 1H), 2.73-2.94 (m, 2H), 2.97 (s, 6H), 5.02 (s, 2H), 5.14-5.21 (m, 1H), 7.25-7.35 (m, 4H), 7.58 (t, J=7.80, 15.94 Hz, 1H), 7.83 (d, J=8.14 Hz, 1H), 8.03 (d, J=8.14 Hz, 1H), 8.93(s, 1H), 9.77 (s, 1H). Calc for C25H31N5O2.1.7HCl: C, 60.60; H, 6.65; N, 14.13. Found: C, 60.91; H, 6.87; N, 13.85. MS (DCI/NH3) m/z 434.

Provenance & Evidence