Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | HCID 15570238 | HCID 15570238 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | HCID 57741239 | HCID 57741239 | — |
Reaction Steps
21.8 g (32 mmol) imidazole are placed in 400 ml chloroform and cooled to 0° C. 21.3 g (15.0 mol) (R)-tetrahydrofuran-2-carbonyl chloride are added dropwise, then the mixture is stirred for 1.5 hours at ambient temperature. After cooling again to 0° C. the reaction mixture is extracted with semisaturated sodium chloride solution. The organic phase is dried and evaporated to dryness. Yield: 24.0 g
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08232286B2 |
|---|
| Source dataset | uspto-grants-2012_07 |
|---|
| ORD ID | ord-ef56a1cdb36d42f6b29675e154c89823 |
|---|
| Source note | uspto-grants-2012_07 |
|---|
