反应详情

温度

0 °C

21.8 g (32.0 mmol) imidazole are placed in 400 ml chloroform and cooled to 0° C. 21.5 g (15.0 mmol) (S)-tetrahydrofuran-2-carbonyl chloride are added dropwise, then stirred for 1.5 hours at ambient temperature. After cooling again to 0° C. the reaction mixture is extracted with semisaturated sodium chloride solution. The organic phase is dried and evaporated to dryness. Yield: 23.5 g

1. temperatureAfter cooling again to 0° C. the reaction mixture
2. extractionis extracted with semisaturated sodium chloride solution
3. customThe organic phase is dried
4. customevaporated to dryness