HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methyl-4-(4-nitrophenyl)piperazine → 4-(4-Methylpiperazin-1-yl)aniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methyl-4-(4-nitrophenyl)piperazine | HCID 2825198 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-(4-Methylpiperazin-1-yl)aniline | HCID 737253 | — |
Reaction Steps
10.0 g (45 mmol) 1-methyl-4-(4-nitro-phenyl)-piperazine are dissolved in 250 ml of ethanol, then combined with 2 g palladium/charcoal (10%) and hydrogenated at 5 bar hydrogen for 2 hours. Then the reaction mixture is suction filtered and the filtrate is concentrated by evaporation. The residue is recrystallised from cyclohexane. Yield: 7.7 g
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08232286B2 |
| Source dataset | uspto-grants-2012_07 |
| ORD ID | ord-eb33d85f80044de9a9a41b6671e39dcb |
| Source note | uspto-grants-2012_07 |