HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methyl-4-(4-nitrophenyl)piperidine → 4-(1-Methylpiperidin-4-yl)aniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methyl-4-(4-nitrophenyl)piperidine | HCID 21959531 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-(1-Methylpiperidin-4-yl)aniline | HCID 21959529 | — |
Reaction Steps
4.3 g (19.5 mmol) 1-methyl-4-(4-nitro-phenyl)-piperidine are dissolved in a mixture of 60 ml of ethanol and 60 ml THF, combined with 2 g palladium/charcoal (10%) and hydrogenated at 1 bar hydrogen. Then the reaction mixture is suction filtered and the filtrate is concentrated by evaporation. Yield: 3.5 g
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08232286B2 |
| Source dataset | uspto-grants-2012_07 |
| ORD ID | ord-4e59960bccd64f0c931cc4f38cfff7d2 |
| Source note | uspto-grants-2012_07 |