HCID 178426490, compound → HCID 57741206, compound

HRID 1517659Notes

Reaction equation

HRID 1517659 reaction equation
C([N:8](CC1C=CC=CC=1)[C@H:9]1[CH2:14][CH2:13][C@@H:12]([N:15]2[CH2:20][CH2:19][C:18]([CH3:22])([CH3:21])[CH2:17][CH2:16]2)[CH2:11][CH2:10]1)C1C=CC=CC=1>CO.[Pd]>[CH3:21][C:18]1([CH3:22])[CH2:19][CH2:20][N:15]([CH:12]2[CH2:13][CH2:14][CH:9]([NH2:8])[CH2:10][CH2:11]2)[CH2:16][CH2:17]1

Participants

4

Reactant 1

HCID 178426490HCID 178426490, compound

Product 1

HCID 57741206HCID 57741206, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

0.7 g (1.8 mmol) cis-dibenzyl-[4-(4,4-dimethyl-piperidin-1-yl)-cyclohexyl]-amine are placed in 14 ml of methanol, 0.14 g palladium/charcoal (10%) are added and the mixture is hydrogenated at 50 psi and 20° C. Then the catalyst is suction filtered and the mother liquor is concentrated by evaporation. Yield: 0.3 g

Workup

  1. customis hydrogenated at 50 psi and 20° C
  2. filtrationfiltered
  3. concentrationthe mother liquor is concentrated by evaporation

Sources & evidence

ORD record
ord-2d53ad08979945cfa6d9ae829d9dfea4
Source dataset
uspto-grants-2012_07
Patent number
US08232286B2

Reaction notes

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