HCID 178420348, compound → HCID 178511572, compound

HRID 1517660Notes

Reaction equation

HRID 1517660 reaction equation
C([N:8](CC1C=CC=CC=1)[C@H:9]1[CH2:14][CH2:13][C@H:12]([N:15]2[CH2:19][CH2:18][CH2:17][CH2:16]2)[CH2:11][CH2:10]1)C1C=CC=CC=1>CO.[Pd]>[N:15]1([C@H:12]2[CH2:13][CH2:14][C@H:9]([NH2:8])[CH2:10][CH2:11]2)[CH2:16][CH2:17][CH2:18][CH2:19]1

Participants

4

Reactant 1

HCID 178420348HCID 178420348, compound

Product 1

HCID 178511572HCID 178511572, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

2.2 g (6.1 mmol) trans-dibenzyl-(4-pyrrolidin-1-yl-cyclohexyl)-amine are placed in 40 ml of methanol and 0.4 g palladium/charcoal (10%) are added. The mixture is hydrogenated at 5 bar and 20° C. Then the catalyst is suction filtered, the mother liquor is combined with conc. hydrochloric acid and concentrated by evaporation. The residue is stirred out with acetone.

Workup

  1. customis hydrogenated at 5 bar and 20° C
  2. filtrationfiltered
  3. concentrationconcentrated by evaporation

Sources & evidence

ORD record
ord-fae28d6f4e8e448f8d5c9552adf140c5
Source dataset
uspto-grants-2012_07
Patent number
US08232286B2

Reaction notes

Loading…