反应详情

4.1 g (11 mmol) cis-dibenzyl-[4-(4-methyl-piperazin-1-yl)-cyclohexyl]-amine are placed in 80 ml of methanol, 0.8 g palladium/charcoal (10%) are added and then the mixture is hydrogenated at 50 psi and 20° C. The reaction mixture is suction filtered through kieselguhr, the mother liquor is concentrated by evaporation. Yield: 1.90 g. The trans-isomer may be prepared analogously.

1. customis hydrogenated at 50 psi and 20° C
2. filtrationfiltered through kieselguhr
3. concentrationthe mother liquor is concentrated by evaporation
4. customThe trans-isomer may be prepared analogously