HCID 178481018, compound → HCID 178481017, compound

HRID 1517663Notes

Reaction equation

HRID 1517663 reaction equation
C([N:8](CC1C=CC=CC=1)[C@H:9]1[CH2:14][CH2:13][C@@H:12]([N:15]2[CH2:20][CH2:19][N:18]([CH3:21])[CH2:17][CH2:16]2)[CH2:11][CH2:10]1)C1C=CC=CC=1>CO.[Pd]>[CH3:21][N:18]1[CH2:17][CH2:16][N:15]([C@H:12]2[CH2:13][CH2:14][C@H:9]([NH2:8])[CH2:10][CH2:11]2)[CH2:20][CH2:19]1

Participants

4

Reactant 1

HCID 178481018HCID 178481018, compound

Product 1

HCID 178481017HCID 178481017, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

4.1 g (11 mmol) cis-dibenzyl-[4-(4-methyl-piperazin-1-yl)-cyclohexyl]-amine are placed in 80 ml of methanol, 0.8 g palladium/charcoal (10%) are added and then the mixture is hydrogenated at 50 psi and 20° C. The reaction mixture is suction filtered through kieselguhr, the mother liquor is concentrated by evaporation. Yield: 1.90 g. The trans-isomer may be prepared analogously.

Workup

  1. customis hydrogenated at 50 psi and 20° C
  2. filtrationfiltered through kieselguhr
  3. concentrationthe mother liquor is concentrated by evaporation
  4. customThe trans-isomer may be prepared analogously

Sources & evidence

ORD record
ord-cd0c2a2fe9f94edfabb7c7e752a67fa7
Source dataset
uspto-grants-2012_07
Patent number
US08232286B2

Reaction notes

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