Hydrochloric Acid → HCID 57741210, compound

Participants

Reaction Steps

2.9 g (8.71 mmol) N-(4-phenyl-4,7-dihydro-3-thia-1,4,5-triaza-cyclopenta[A]pentalen-2-yl)-acetamide (prepared analogously to Example 58 from intermediate compound 22) are suspended in 20 ml of water and 20 ml 32% hydrochloric acid and refluxed for 2 hours with stirring. After cooling to ambient temperature the mixture is extracted with diethyl ether and the aqueous phase is made basic. The precipitate formed is stirred for 0.25 hours at 5° C., suction filtered and dried. The crude product is suspended in 150 ml of tetrahydrofuran and combined with 5 ml of conc. hydrochloric acid, then stirred for 16 hours at 60° C. After cooling to 5° C. the precipitate is suction filtered and dried.

Provenance & Evidence