HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → (E)-3-(1-phenylmethanesulfonyl-1H-pyrrol-3-yl)-acrylic acid tert-butylester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | Phenylmethanesulfonyl chloride | HCID 74740 | — |
| Reactant | tert-butyl (2E)-3-(1H-pyrrol-3-yl)prop-2-enoate | HCID 66646340 | — |
| Product | (E)-3-(1-phenylmethanesulfonyl-1H-pyrrol-3-yl)-acrylic acid tert-butylester | HCID 66646367 | — |
Reaction Steps
Starting materials: sodium hydride 60% (0.240 g), (E)-3-(1H-pyrrol-3-yl)-acrylic acid tert-butyl ester (compound D1) (1.01 g), α-toluenesulfonylchloride (1.19 g). Reaction conditions: −30° C., 30 min; −30° C., 2.5 hours.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08232297B2 |
| Source dataset | uspto-grants-2012_07 |
| ORD ID | ord-3b0ae160113c403394acafb6aa61acf4 |
| Source note | uspto-grants-2012_07 |