Methanol → (S)-((R)-1-(4-(3-fluoro-4-(7-methoxyquinolin-4-yloxy)phenylcarbamoyl)-5-methyl-3-oxo-2-phenyl-2,3-dihydropyrazol-1-yl)propan-2-yl)2-aminopropanoate phosphoric acid

Participants

Reaction Steps

To a solution of (S)—((R)-1-(4-(3-fluoro-4-(7-methoxyquinolin-4-yloxy)phenyl carbamoyl)-5-methyl-3-oxo-2-phenyl-2,3-dihydropyrazol-1-yl)propan-2-yl)2-amino-propanoate (61.3 mg, 0.1 mmol) in EtOAc (15 mL)/MeOH (10 mL) was added phosphoric acid (19.6 mg, 0.2 mmol). After stirring for 40 min, the mixture was concentrated in vacuo, and the resulted oil was washed with a mixture of MeOH (2 mL)/EtOAc (10 mL) followed by EtOAc (5 mL×3) to give the title compound as yellow oil (67.2 mg, 91.9%).

Provenance & Evidence