p-Toluenesulfonic acid → (S)-1-(4-(3-fluoro-4-(7-methoxyquinolin-4-yloxy)phenylcarbamoyl)-5-methyl-3-oxo-2-phenyl-2,3-dihydropyrazol-1-yl)propan-2-yl 2-(dimethylamino)acetate 4-methylbenzenesulfonate

Participants

Reaction Steps

The title compound was prepared according to the procedure described in Example 35 step 2 by using the compound of (S)-1-(4-(4-(7-methoxyquinolin-4-yloxy)-3-fluoro-phenylcarbamoyl)-2,3-dihydro-5-methyl-3-oxo-2-phenylpyrazol-1-yl)propan-2-yl 2-(dimethylamino)acetate (62.9 mg, 0.1 mmol) and p-toluene sulphonic acid (34.6 mg, 0.2 mmol, Shanghai chemical reagent factory). The desired compound was abtained as a yellow solid (56.1 mg, 57%).

Provenance & Evidence