HuagongsheHuagongshe Chemistry Print Report · For research reference only
Citric Acid → HCID 66669824, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Citric Acid | HCID 311 | — |
| Reactant | (R)-1-(4-(3-fluoro-4-(7-methoxyquinolin-4-yloxy)phenylcarbamoyl)-5-methyl-3-oxo-2-phenyl-2,3-dihydropyrazol-1-yl)propan-2-yl 2-(methylamino)acetate | HCID 46937772 | — |
| Product | HCID 66669824 | HCID 66669824 | — |
Reaction Steps
The title compound was prepared according to the procedure described in Example 39 step 3 by using (R)-1-(4-(4-(7-methoxyquinolin-4-yloxy)-3-fluorophenylcarbamoyl)-2,3-dihydro-5-methyl-3-oxo-2-phenylpyrazol-1-yl)propan-2-yl 2-(methylamino)acetate (82.3 mg, 0.134 mmol) and citric acid (51.5 mg, 0.268 mmol, Tianjin Chemical Factory). The title compound was abtained as a pale yellow solid (90.6 mg, 84%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08232294B2 |
| Source dataset | uspto-grants-2012_07 |
| ORD ID | ord-5fb13403dc95404c8cb733b408d41044 |
| Source note | uspto-grants-2012_07 |