反应详情

To a solution of 3-fluoro-4-(7-methoxyquinolin-4-yloxy)benzenamine (399 mg, 1.38 mmol), (R)-1-(2-(2-(tert-butoxycarbonylamino)acetoxy)propyl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid (500 mg, 1.15 mmol) in dry CH2Cl2 (5 mL) was added EDCI (264 mg, 1.38 mmol) and HOAT (32 mg, 0.23 mmol). The mixture reaction was refluxed for 3 h. The reaction mixture was then concentrated in vacuo and the residue was purified by a silica gel column chromatography (100% EtOAc) to give the title compound as a white solid (610 mg, 76%).

1. customThe mixture reaction
2. temperaturewas refluxed for 3 h
3. concentrationThe reaction mixture was then concentrated in vacuo
4. customthe residue was purified by a silica gel column chromatography (100% EtOAc)