Fumaric Acid → (R)-1-(4-(3-fluoro-4-(7-methoxyquinolin-4-yloxy)phenylcarbamoyl)-5-methyl-3-oxo-2-phenyl-2,3-dihydropyrazol-1-yl)propan-2-yl 2-(dimethylamino)acetate fumarate

Participants

Reaction Steps

The title compound was prepared according to the procedure described in Example 54 step 2 by using (R)-1-(4-(4-(7-methoxyquinolin-4-yloxy)-3-fluorophenylcarbamoyl)-2,3-dihydro-5-methyl-3-oxo-2-phenylpyrazol-1-yl)propan-2-yl 2-(dimethylamino)acetate (100 mg, 0.16 mmol) and fumaric acid (55.44 mg, 0.48 mmol, Shantou Xilong Chemical Factory). The title compound was obtained as a yellow solid (78.7 mg, 66%).

Provenance & Evidence