Fumaric Acid → HCID 46938117, compound

HRID 1517858Notes

Reaction equation

[CH3:1][NH:2][CH2:3][C:4]([O:6][C@H:7]([CH3:44])[CH2:8][N:9]1[C:13]([CH3:14])=[C:12]([C:15](=[O:36])[NH:16][C:17]2[CH:22]=[CH:21][C:20]([O:23][C:24]3[C:33]4[C:28](=[CH:29][C:30]([O:34][CH3:35])=[CH:31][CH:32]=4)[N:27]=[CH:26][CH:25]=3)=[CH:19][N:18]=2)[C:11](=[O:37])[N:10]1[C:38]1[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=1)=[O:5].[C:45]([OH:52])(=[O:51])/[CH:46]=[CH:47]/[C:48]([OH:50])=[O:49]>>[C:45]([OH:52])(=[O:51])/[CH:46]=[CH:47]/[C:48]([OH:50])=[O:49].[CH3:1][NH:2][CH2:3][C:4]([O:6][C@H:7]([CH3:44])[CH2:8][N:9]1[C:13]([CH3:14])=[C:12]([C:15](=[O:36])[NH:16][C:17]2[CH:22]=[CH:21][C:20]([O:23][C:24]3[C:33]4[C:28](=[CH:29][C:30]([O:34][CH3:35])=[CH:31][CH:32]=4)[N:27]=[CH:26][CH:25]=3)=[CH:19][N:18]=2)[C:11](=[O:37])[N:10]1[C:38]1[CH:39]=[CH:40][CH:41]=[CH:42][CH:43]=1)=[O:5]

Participants

Reactant 2

HCID 444972Fumaric Acid

HCID 46938058HCID 46938058, compound

Product 1

HCID 46938117HCID 46938117, compound

Procedure

The title compound was prepared according to the procedure described in Example 59 Step 3 by using (R)-1-(4-(5-(7-methoxyquinolin-4-yloxy)pyridin-2-ylcarbamoyl)-2,3-dihydro-5-methyl-3-oxo-2-phenylpyrazol-1-yl)propan-2-yl 2-(methylamino)acetate (100 mg, 0.168 mmol) and fumaric acid (58.4 mg, 0.50 mmol, Shantou Xilong Chemical Factory). The title compound was obtained as a yellow solid (94.1 mg, 79%).

Workup

customThe title compound was prepared

Sources & evidence

ORD record: ord-b19526fef1b54884aca2640f497e94de
Source dataset: uspto-grants-2012_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08232294B2

Reaction notes

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