Acetic Acid → HCID 66669795, compound

HRID 1517859Notes

Reaction equation

HRID 1517859 reaction equation
[C:1]([OH:4])(=[O:3])[CH3:2].[CH3:5][NH:6][CH2:7][C:8]([O:10][C@H:11]([CH3:48])[CH2:12][N:13]1[C:17]([CH3:18])=[C:16]([C:19](=[O:40])[NH:20][C:21]2[CH:26]=[CH:25][C:24]([O:27][C:28]3[C:37]4[C:32](=[CH:33][C:34]([O:38][CH3:39])=[CH:35][CH:36]=4)[N:31]=[CH:30][CH:29]=3)=[CH:23][N:22]=2)[C:15](=[O:41])[N:14]1[C:42]1[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=1)=[O:9]>>[C:1]([OH:4])(=[O:3])[CH3:2].[CH3:5][NH:6][CH2:7][C:8]([O:10][C@H:11]([CH3:48])[CH2:12][N:13]1[C:17]([CH3:18])=[C:16]([C:19](=[O:40])[NH:20][C:21]2[CH:26]=[CH:25][C:24]([O:27][C:28]3[C:37]4[C:32](=[CH:33][C:34]([O:38][CH3:39])=[CH:35][CH:36]=4)[N:31]=[CH:30][CH:29]=3)=[CH:23][N:22]=2)[C:15](=[O:41])[N:14]1[C:42]1[CH:43]=[CH:44][CH:45]=[CH:46][CH:47]=1)=[O:9]

Participants

3

Reactant 2

HCID 176Acetic AcidHCID 46938058HCID 46938058, compound

Product 1

HCID 66669795HCID 66669795, compound

Procedure

The title compound was prepared according to the procedure described in Example 59 Step 3 by using acetic acid (30.21 mg, 0.50 mmol, Shantou Xilong Chemical Factory) and (R)-1-(4-(5-(7-methoxyquinolin-4-yloxy)pyridin-2-ylcarbamoyl)-2,3-dihydro-5-methyl-3-oxo-2-phenylpyrazol-1-yl)propan-2-yl 2-(methylamino)acetate (100 mg, 0.168 mmol). The title compound was obtained as a yellow solid (81.4 mg, 73.7%).

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-5dbd14f63b604daca7550f71226149b3
Source dataset
uspto-grants-2012_07
Patent number
US08232294B2

Reaction notes

Loading…