HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 66669827, compound → HCID 136346386, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 66669827 | HCID 66669827 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 136346386 | HCID 136346386 | 99.5% |
Reaction Steps
To a solution of tert-butyl 4-(7-(benzyloxy)-6-methoxyquinolin-4-yloxy)-3-fluorophenylcarbamate (800 mg, 1.632 mmol) in ethanol (50 mL) was added a catalytic amount of Pd/C. The suspension was stirred at rt under H2 for 3 h. The reaction mixture was filtered, and the filtrate was concentrated in vacuo to give the title compound as a light green solid (650 mg, 99%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08232294B2 |
| Source dataset | uspto-grants-2012_07 |
| ORD ID | ord-8d897b425bfc48c3b903d32a1d07e5ea |
| Source note | uspto-grants-2012_07 |