Potassium Carbonate → HCID 66669893, compound

Participants

Reaction Steps

To a solution of tert-butyl 3-fluoro-4-(7-hydroxy-6-methoxyquinolin-4-yloxy)phenylcarbamate (400 mg, 1 mmol) in DMF (4 mL) was added K2CO3 (276 mg, 2 mmol) and 3-bromopropan-1-ol (154 mg, 1.1 mmol). The reaction was stirred at rt overnight. The solvent was removed, and the residue was partitioned between water (10 mL) and CH2Cl2 (20 mL). The organic layer was separated, dried over Na2SO4 and concentrated in vacuo. The residue was purified by a silica gel column chromatography (EtOAC to 10% methanol in EtOAC) to give the title compound as a light yellow solid (300 mg, 65%).

Provenance & Evidence