Dimethylamine → HCID 59335117, compound

Participants

Reaction Steps

300 mg 6-(3,5-dichloro-phenylsulphonylamino)-1-methyl-1H-indole-3-carboxylic acid are dissolved in 2 ml dimethylformamide, combined with 319 μl N,N-diisopropyl-N-ethyl-amine and 241 mg O-(benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium-tetrafluoroborate (TBTU) and stirred for 15 minutes at ambient temperature. 751 μl of a 2 M solution of dimethylamine in tetrahydrofuran are added and the mixture is stirred overnight at ambient temperature. Then it is divided between water and ethyl acetate, the aqueous phase is extracted with ethyl acetate and the combined organic phases are dried on magnesium sulphate. The solvents are eliminated in vacuo.

Provenance & Evidence