反应详情

100 mg methyl 5-[tert-butoxycarbonylmethyl-(3,5-dichloro-phenylsulphonyl)-amino]-1-methylcarbamoyl-2,3-dihydro-1H-indole-3-carboxylate are dissolved in 1.2 ml of tetrahydrofuran, combined with 349 μl of a 1 M solution of lithium hydroxide in water and stirred overnight at ambient temperature. Then the mixture is cooled to 0° C., combined with 350 μl 1 M hydrochloric acid and divided between ethyl acetate and saturated sodium chloride solution. The organic phase is dried on magnesium sulphate and the solvents are eliminated in vacuo. The residue is chromatographed on silica gel (dichloromethane/methanol 20:1).

1. temperatureThen the mixture is cooled to 0° C.
2. customThe organic phase is dried on magnesium sulphate
3. customThe residue is chromatographed on silica gel (dichloromethane/methanol 20:1)