Acetic Anhydride → HCID 25097753, compound

HRID 1517974Notes

Reaction equation

HRID 1517974 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([S:9]([N:12]([CH2:22][C:23]([OH:25])=[O:24])[C:13]2[CH:14]=[C:15]3[C:19](=[CH:20][CH:21]=2)[NH:18][CH2:17][CH2:16]3)(=[O:11])=[O:10])[CH:5]=[C:6]([Cl:8])[CH:7]=1.[C:26](OC(=O)C)(=[O:28])[CH3:27]>ClCCl>[C:26]([N:18]1[C:19]2[C:15](=[CH:14][C:13]([N:12]([CH2:22][C:23]([OH:25])=[O:24])[S:9]([C:4]3[CH:5]=[C:6]([Cl:8])[CH:7]=[C:2]([Cl:1])[CH:3]=3)(=[O:10])=[O:11])=[CH:21][CH:20]=2)[CH2:16][CH2:17]1)(=[O:28])[CH3:27]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 59334999HCID 59334999, compound

Product 1

HCID 25097753HCID 25097753, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

40 mg [(3,5-dichloro-phenylsulphonyl)-(2,3-dihydro-1H-indol-5-yl)-amino]-acetic acid are dissolved in 2 ml dichloromethane. 100 μl acetic anhydride are added and the mixture is stirred overnight at ambient temperature. The volatile constituents are eliminated in vacuo and the residue is purified by chromatography on silica gel with dichloromethane/methanol (99:1 to 85:15). The product thus obtained is extracted from diethyl ether/diisopropylether. The solid is suction filtered and dried in vacuo.

Workup

  1. customthe residue is purified by chromatography on silica gel with dichloromethane/methanol (99:1 to 85:15)
  2. customThe product thus obtained
  3. extractionis extracted from diethyl ether/diisopropylether
  4. filtrationfiltered
  5. customdried in vacuo

Sources & evidence

ORD record
ord-9e06939c9b0d46a58e9f94da55e5d890
Source dataset
uspto-grants-2012_07
Patent number
US08232312B2

Reaction notes

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