HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → HCID 57904058, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | HCID 57904117 | HCID 57904117 | — |
| Catalyst | Benzyl triethylammonium chloride | HCID 66133 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Sodium Hydroxide | HCID 14798 | — |
| Product | HCID 57904058 | HCID 57904058 | — |
Reaction Steps
If one were to take 3 mmole of quinolone 5 from Step D dissolved in tetrahydrofuran (THF) and treat it with 1.5 equivalents of methyl iodide, 0.5 equivalents of benzyltriethylammonium chloride in 10 N aqueous sodium hydroxide and stir the resulting mixture for 24 hours followed by organic extraction with methylene chloride one would produce the resulting product, 6-(5-chloro-thiophene-2-carbonyl)-4-(3-iodo-phenyl)-1-methyl-1H-quinolin-2-one (6).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08232402B2 |
| Source dataset | uspto-grants-2012_07 |
| ORD ID | ord-906a189773a94f79b939163ad72ae919 |
| Source note | uspto-grants-2012_07 |