1-Oxa-2-azaspiro[4.5]dec-2-ene-3-carboxylic acid → 1-Oxa-2-aza-spiro[4.5]dec-2-ene-3-carboxylic acid [4-nitro-6-(2-trifluoromethyl-phenyl)-pyridin-3-yl]-amide

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Reaction Steps

The title compound was prepared from 4-nitro-6-(2-trifluoromethyl-phenyl)-pyridin-3-ylamine (as prepared in the previous step) and 1-oxa-2-aza-spiro[4.5]dec-2-ene-3-carboxylic acid (as prepared in Example 1, step B) according to the procedure described in Example 16, step D. 1H-NMR (400 MHz, CDCl3) δ: 9.45 (s, 1H), 8.93 (s, 1H), 7.80 (d, J=7.3 Hz, 1H), 7.65 (t, J=7.1 Hz, 1H), 7.59 (t, J=7.5 Hz, 1H), 7.51 (d, J=7.6 Hz, 1H), 2.97 (s, 2H), 1.73-1.90 (m, 5H), 1.62-1.73 (m, 3H), 1.40-1.54 (m, 2H). Mass Spectrum (LCMS, ESI pos.): Calcd. for C21H19F3N4O4: 449.1 (M+H). found: 449.2.

Provenance & Evidence