3-Methoxypropyne → 5-(3-Methoxy-propyl)-2'-trifluoromethyl-biphenyl-3,4-diamine

HRID 1518160Notes

Reaction equation

I[C:2]1[CH:3]=[C:4]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[C:18]([F:21])([F:20])[F:19])[CH:5]=[C:6]([N+:9]([O-])=O)[C:7]=1[NH2:8].[CH3:22][O:23][CH2:24][C:25]#[CH:26]>>[CH3:22][O:23][CH2:24][CH2:25][CH2:26][C:2]1[C:7]([NH2:8])=[C:6]([NH2:9])[CH:5]=[C:4]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[C:18]([F:21])([F:20])[F:19])[CH:3]=1

Participants

Reactant 2

HCID 693933-Methoxypropyne

HCID 509942803-Iodo-5-nitro-2'-trifluoromethyl-biphenyl-4-ylamine

Product 1

HCID 592800905-(3-Methoxy-propyl)-2'-trifluoromethyl-biphenyl-3,4-diamine

Procedure

The title compound was prepared from 3-iodo-5-nitro-2′-trifluoromethyl-biphenyl-4-ylamine (as prepared in Example 9, step A) and 3-methoxy-propyne according to the procedures described in Example 10, steps A and B.

Sources & evidence

ORD record: ord-d7f778c1c5f446c1987b4c03f9e5b21e
Source dataset: uspto-grants-2012_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08232409B2

Reaction notes

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