1-Oxa-2-azaspiro[4.5]dec-2-ene-3-carboxylic acid → HCID 178421912, compound

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Reaction Steps

The title compound was prepared from N-(5-chloro-2-methyl-3-nitro-2′-trifluoromethyl-biphenyl-4-yl)-acetamide (as prepared in the previous step) and 1-oxa-2-aza-spiro[4.5]dec-2-ene-3-carboxylic acid (as prepared in Example 1, step B) according to the procedures described in Example 1, steps E through H. 1H-NMR (400 MHz, d6-DMSO) δ: 7.87 (d, J=7.6 Hz, 1H), 7.75 (t, J=7.3 Hz, 1H), 7.66 (t, J=7.7 Hz, 1H), 7.40 (d, J=7.3 Hz, 1H), 7.07 (s, 1H), 3.34 (s, 2H), 2.16 (s, 3H), 1.62-1.83 (m, 6H), 1.31-1.61 (m, 4H). Mass Spectrum (LCMS, ESI pos.): Calcd. for C23H21ClF3N3O: 448.1 (M+H). found: 448.3.

Provenance & Evidence