2-Methyl-3-butyn-2-ol → 4-(4,5-Diamino-2'-trifluoromethyl-biphenyl-3-yl)-2-methyl-butan-2-ol

HRID 1518165Notes

Reaction equation

HRID 1518165 reaction equation
I[C:2]1[CH:3]=[C:4]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[C:18]([F:21])([F:20])[F:19])[CH:5]=[C:6]([N+:9]([O-])=O)[C:7]=1[NH2:8].[CH3:22][C:23]([OH:27])([C:25]#[CH:26])[CH3:24]>>[NH2:8][C:7]1[C:6]([NH2:9])=[CH:5][C:4]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[C:18]([F:21])([F:20])[F:19])=[CH:3][C:2]=1[CH2:26][CH2:25][C:23]([CH3:24])([OH:27])[CH3:22]

Participants

3

Reactant 2

HCID 82582-Methyl-3-butyn-2-olHCID 509942803-Iodo-5-nitro-2'-trifluoromethyl-biphenyl-4-ylamine

Product 1

HCID 592801034-(4,5-Diamino-2'-trifluoromethyl-biphenyl-3-yl)-2-methyl-butan-2-ol

Procedure

The title compound was prepared from 3-iodo-5-nitro-2′-trifluoromethyl-biphenyl-4-ylamine (as prepared in Example 9, step A) and 2-methyl-but-3-yn-2-ol according to the procedures described in Example 10, steps A and B.

Sources & evidence

ORD record
ord-d525f0a45b444f94a1a155a91bb3a17d
Source dataset
uspto-grants-2012_07
Patent number
US08232409B2

Reaction notes

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